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Literature summary extracted from

  • Trueblood, C.E.; Boyartchuk, V.L.; Picologlou, E.A.; Rozema, D.; Poulter, C.D.; Rine, J.
    The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities (2000), Mol. Cell. Biol., 20, 4381-4392.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.99.B1 E139K increase in proteolysis of a-factor-CAMQ Saccharomyces cerevisiae
3.4.99.B1 F189L increase in proteolysis of a-factor-CAMQ Saccharomyces cerevisiae
3.4.99.B1 Q201R increase in proteolysis of a-factor-CAMQ Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.84 a-factor-CaaX + H2O Saccharomyces cerevisiae removal of the last three amino acids of carboxyl-terminal sequence motif CaaX, enzyme proteolyzes a-factor with A,V, L, I, C or M at the a1 position, V, L, I, C or M at the a2 position or any amino acid at the X position a-factor + aaX
-
 ?
3.4.99.B1 a-factor-CaaX + H2O Saccharomyces cerevisiae removal of the last three amino acids of carboxyl-terminal sequence motif CaaX, enzyme proteolyzes a-factor with A, V, L, I, C or M at the a1 position, V, L, I, C or M at the a2 position or any amino acid at the X position a-factor-C + aaX
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.84 Saccharomyces cerevisiae
-
-
-
3.4.99.B1 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.84 a-factor-CaaX + H2O removal of the last three amino acids of carboxyl-terminal sequence motif CaaX, enzyme proteolyzes a-factor with A, V, L, I, C or M at the a1 position, V, L, I, C or M at the a2 position or any amino acid at the X position Saccharomyces cerevisiae a-factor + aaX
-
 ?
3.4.24.84 a-factor-CaaX + H2O removal of the last three amino acids of carboxyl-terminal sequence motif CaaX, enzyme proteolyzes a-factor with A,V, L, I, C or M at the a1 position, V, L, I, C or M at the a2 position or any amino acid at the X position Saccharomyces cerevisiae a-factor + aaX
-
 ?
3.4.99.B1 a-factor-CaaX + H2O removal of the last three amino acids of carboxyl-terminal sequence motif CaaX, enzyme proteolyzes a-factor with A, V, L, I, C or M at the a1 position, V, L, I, C or M at the a2 position or any amino acid at the X position Saccharomyces cerevisiae a-factor-C + aaX
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.84 Afc1p
-
 Saccharomyces cerevisiae
3.4.99.B1 Rce1p
-
 Saccharomyces cerevisiae